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Monoclonal Anti-NT-proBNP (Detection Ab)

Product Specifications

Background

The N-terminal prohormone of brain natriuretic peptide (NT-proBNP) is a 76 amino acid N-terminal fragment of brain natriuretic peptide.Both BNP and NT-proBNP levels in the blood are used for screening, diagnosis of acute congestive heart failure (CHF) and may be useful to establish prognosis in heart failure, as both markers are typically higher in patients with worse outcome.BNP may be a useful screening tool for left ventricular dysfunction in patients with history suggestive of heart disease and be usedto assist in forming a pretest probability, which in turn could greatly assist in appropriateness of patient referral and in optimization of drug therapy.

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human NT-proBNP.

Capture Antibody

Capture Ab: NT-proBNP pAb (# BDA1009) ; Detection Ab: NT-proBNP mAb (clone # C7)

Clone

C7

Applications

Western Blot, WB; ELISA; Lateral flow Chemilumineseent immunoassay, CLIA

Purity

>95% by HPLC & SDS-PAGE

Form

Liquid

Buffer

Protein A or G purified and supplied in 0.01 M PBS (pH7.4) without preservative.

References & Citations

1. Bhalla V, Willis S, Maisel AS (2004) . "B-type natriuretic peptide: the level and the drug--partners in the diagnosis of congestive heart failure". Congest Heart Fail 10 (1 Suppl 1) : 3–27. 2. Atisha D, Bhalla MA, Morrison LK, Felicio L, Clopton P, Gardetto N, Kazanegra R, Chiu A, Maisel AS (September 2004) . "A prospective study in search of an optimal B-natriuretic peptide level to screen patients for cardiac dysfunction".Am. Heart J.148 (3) : 518–23.

Storage Conditions

Aliquot and store at -20°C for long term (at least one year). Avoid repeated freeze and thaw cycles.

Specificity

It specifically recognize the human NT-proBNP, and does not cross react with BNP and cardiac Troponin I.

Isotype

IgG1

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