Monoclonal Anti- Bone morphogenetic protein receptor type II, BMPR2 antibody

Bone morphogenetic protein receptor type II, BMPR2 is a serine/threonine receptor kinase. It bindsbone morphogenetic proteins, members of the TGF beta superfamily of ligands. BMPs are involved in a host of cellular functions including osteogenesis, cell growth and cell differentiation.Unlike the TGFβtype II receptor, which has a high affinity for TGF-β1, BMPR2 does not have a high affinity for BMP-2, BMP-7 and BMP-4, unless it is co-expressed with a type I BMP receptor.1The low affinity for ligands suggests that BMPR2 may differ in the from other type II TGF beta receptors in that the ligand may bind the type I receptor first.2

Gilboa, L; Nohe A, Geissendorfer T, Sebald W, Henis YI, Knaus P. (March 2000) . "Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors". Mol Biol Cell. 11 (3) . Kirsch, T; Nickel J, Sebald W. (July 2000) . "BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II". EMBO J. 19 (13) : 3314.