Monoclonal Anti- Tyrosine Hydroxylase, TH antibody

Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA) . In humans, tyrosine hydroxylase is encoded by the TH gene, and the enzyme is present in the central nervous system (CNS), peripheral symphatic neurons and the adrenal medulla. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. It also can be inhibited by the drug α-methyl-para-tyrosine (metirosine) . This drug is rarely used and can cause depression, but it is useful in treating pheochromocytoma and also resistant hypertension.

1. Hedstrand H, Ekwall O, Haavik J, Landgren E, Betterle C, Perheentupa J, Gustafsson J, Husebye E, Rorsman F, Kämpe O (2000) . "Identification of Tyrosine Hydroxylase as an Autoantigen in Autoimmune Polyendocrine Syndrome Type I". Biochemical and Biophysical Research Communications 267 (1) : 456–461. 2. Nagatsu T (1995) . "Tyrosine hydroxylase: human isoforms, structure and regulation in physiology and pathology". Essays Biochem. 30: 15–35. 3. Kaufman S (1995) . "Tyrosine hydroxylase". Adv. Enzymol. Relat. Areas Mol. Biol.. Advances in Enzymology - and Related Areas of Molecular Biology 70: 103–220.