Monoclonal Anti- Prealbumin, PA antibody

Prealbumin (PA), as known as Transthyretin (TTR), is an evolutionarily conserved serum and cerebrospinal fluid (CSF) protein that transports holo-retinol-binding protein (RBP) and thyroxine (T4) . It is a 62-kDa homotetramer with a dimer of dimers quaternary structure that is synthesized mainly in liver, choroid plexus, retinal pigment epithelium for secretion into the bloodstream, cerebrospinal fluid and the eye, respectively. It maintains normal levels of retinol, retinol-binding protein, and thyroid hormone in the circulating plasma.[1]TTR misfolding and aggregation is known to be associated with the amyloid diseases[2]senile systemic amyloidosis (SSA), [3]familial amyloid polyneuropathy (FAP), [4]and familial amyloid cardiomyopathy (FAC) .[5]

Episkopou, V., Maeda, S., Nishiguchi, S., Shimada, K., Gaitanaris, G. A., Gottesman, M. E., Robertson, E. J. Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone. Proc. Nat. Acad. Sci. 90: 2375-2379, 1993. Zeldenrust SR, Benson MD (2010) . "Familial and senile amyloidosis caused by transthyretin". In Ramirez-Alvarado M, Kelly JW, Dobson C. Protein misfolding diseases: current and emerging principles and therapies. New York: Wiley. Westermark P, Sletten K, Johansson B, Cornwell GG (April 1990) . "Fibril in senile systemic amyloidosis is derived from normal transthyretin". Proc. Natl. Acad. Sci. U.S.A. 87 (7) : 2843–5. Andrade C (September 1952) . "A peculiar form of peripheral neuropathy; familiar atypical generalized amyloidosis with special involvement of the peripheral nerves". Brain 75 (3) : 408–27. Jacobson DR, Pastore RD, Yaghoubian R, Kane I, Gallo G, Buck FS, Buxbaum JN (February 1997) . "Variant-sequence transthyretin (isoleucine 122) in late-onset cardiac amyloidosis in black Americans". N. Engl. J. Med. 336 (7) : 466–73.