Monoclonal Anti- Lymphotoxin-alpha, LTα/ TNFβ antibody

Product Specifications

Background

Lymphotoxin-alpha, a member of theHYPERLINK "http://en.wikipedia.org/wiki/Tumor_necrosis_factors" \o "Tumor necrosis factors"tumor necrosis factor family, is a cytokine produced byHYPERLINK "http://en.wikipedia.org/wiki/Lymphocyte" \o "Lymphocyte"lymphocytes.It is a glycoprotein with a relative molecular mass (Mr) of 60,000-70,000.[1]LTA is highly inducible, secreted, and exists as homotrimeric molecule. It forms heterotrimers withHYPERLINK "http://en.wikipedia.org/wiki/LTB" \o "LTB"lymphotoxin-betawhich anchors lymphotoxin-alpha to the cell surface.LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. It is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.[2]

Host

Mouse

Reactivity

Human, rat

Immunogen

A synthetic peptide (conjugated with KLH) corresponding to the region of humanLT-alpha.

Clone

M42-5

Applications

Western Blot, WB (1:100-200) ; ELISA (1:5, 000)

Purification

Protein A purified

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol and 0.05% Sodium Azide.

References & Citations

Gray, P. W., Aggarwal, B. B., Benton, C. V., Bringman, T. S., Henzel, W. J., Jarrett, J. A., Leung, D. W., Moffat, B., Ng, P., Svedersky, L. P., Palladino, M. A., Nedwin, G. E. Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity. Nature 312: 721-724, 1984. Aggarwal BB, Eessalu TE, Hass PE (Feb 1986) . "Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon". Nature 318 (6047) : 665–7.