Monoclonal Anti- Lactate dehydrogenase A, LDH-A antibody
Product Specifications
Background
Lactate dehydrogenase A, also known as LDHA, is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. It is encoded by the LDHA gene which contains 7 exons and spans about 12 kb[1]. It catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis.[2]Mutations in LDHA have been linked to exertional myoglobinuria.
Host
Mouse
Reactivity
Human, mouse
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to the N-terminal of human LDH-A.
Clone
L46-2
Applications
Western Blot, WB (1:100-200) ; Immunohistochemistry, IHC-P (1:20)
Purification
Protein A purified
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol and 0.05% Sodium Azide.
References & Citations
Chung, F.-Z., Tsujibo, H., Bhattacharyya, U., Sharief, F. S., Li, S. S.-L. Genomic organization of human lactate dehydrogenase-A gene. Biochem. J. 231: 537-541, 1985. Tsujibo, H., Tiano, H. F., Li, S. S.-L. Nucleotide sequences of the cDNA and an intronless pseudogene for human lactate dehydrogenase-A isozyme. Europ. J. Biochem. 147: 9-15, 1985.
Storage Conditions
Store at 4°C after thawing (1 week). Aliquot and store at -20°C for long term (at least one year). Avoid repeated freeze and thaw cycles.
Isotype
IgG1
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