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Monoclonal Anti- Junctophilin-2, JPH-2 antibody

Product Specifications

Background

Junctophilin 2, also known as JPH2, is a member of the junctophilin gene family (the other members of the family areHYPERLINK "http://en.wikipedia.org/wiki/JPH1" \o "JPH1"JPH1, HYPERLINK "http://en.wikipedia.org/wiki/JPH3" \o "JPH3"JPH3, andHYPERLINK "http://en.wikipedia.org/w/index.php?title=JPH4&action=edit&redlink=1" \o "JPH4 (page does not exist) "JPH4), located between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) . It is the predominant isoform in cardiac tissue, and also expressed with JPH1 in skeletal muscle.HYPERLINK "http://en.wikipedia.org/wiki/JPH2" \l "cite_note-3"[1]JPH2 has been shown to be downregulated in several animal models of heart failure.

Host

Mouse

Reactivity

Human, mouse, rat

Immunogen

A synthetic peptide (conjugated with KLH) corresponding to the region of human JPH-2.

Clone

D5-3

Applications

Western Blot, WB (1:200-500) ; Immunohistochemistry, IHC-P (1:50) ; Immunocytochemistry, ICC (1:20-50)

Purification

Protein A purified

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol and 0.05% Sodium Azide.

References & Citations

Garbino A, van Oort RJ, et al. (2009) .HYPERLINK "http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2685503""Molecular evolution of the junctophilin gene family.". Physiol Genomics 37 (3) : 175–86.

Storage Conditions

Store at 4°C after thawing (1 week). Aliquot and store at -20°C for long term (at least one year). Avoid repeated freeze and thaw cycles.

Isotype

IgG1

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