Monoclonal Anti- Human Serum Albumin antibody

Human serum albumin is the most abundant protein in human blood plasma. It is produced in the liver, and cleaved in the Golgi vesicles. It has a molecular mass of 67 kDa. Albumin transports hormones, fatty acids, and other compounds, buffers pH, and maintains osmotic pressure.[1] As a negative acute-phase protein, is down-regulated in inflammatory states. As such, it is not a valid marker of nutritional status; rather, it is a marker in inflammatory states. Human albumin is often used to replace lost fluid and help restore blood volume in trauma, burns and surgery patients. [2]

1. Masaki T, Matsuura T, Ohkawa K, Miyamura T, Okazaki I, Watanabe T, Suzuki T (July 2006) . "All-trans retinoic acid down-regulates human albumin gene expression through the induction of C/EBPβ-LIP". Biochem. J. 397 (2) : 345–53. 2. The Albumin Reviewers (Alderson P, Bunn F, Li Wan Po A, Li L, Pearson M, Roberts I, Schierhout G) . Human albumin solution for resuscitation and volume expansion in critically ill patients. Cochrane Database of Systematic Reviews 2004, Issue 4. Art. No.: CD001208.