Monoclonal Anti- Heat shock protein 60, HSP60 antibody

Heat shock protein 60 (HSP60) in the matrix of mitochondria is essential for the folding and assembly of newly imported proteins. Hsp60 belongs to a class of structurally related chaperonins found in organelles of endosymbiotic origin and in the bacterial cytosol.1Members of the chaperonin class include the Escherichia coli, groEL protein and the Rubisco subunit-binding protein of chloroplasts.2In both prokaryotic and eukaryotic systems, synthesis of these proteins is induced in response to stresses, such as heat shock.3Under normal physiological conditions, HSP60 is a 60 KD oligomer composed of monomers that form a complex arranged as two stacked heptameric rings.1HSP60 may be a very useful marker for patients with superficial bladder carcinoma and may be used for predicting disease progression. And low HSP60 expression levels may be usable as a prognostic marker to identify patients for whom local treatment would be insufficient.4HSP60 also linked to diabetes, cancer and certain types of immunological disorders.

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