Monoclonal Anti- Cyclin E2 antibody

Cyclin E2 is a member of the cyclin family, It is a predicted 404-amino acid protein which contains a cyclin box motif and it is 47% identical to cyclin E1.[1]It is expressed in several normal human tissues, with the highest levels in testis, thymus, and brain. Gudas et al. (1999) found that, like cyclin E1, the human cyclin E2 gene complemented a G1 cyclin defect in S.cerevisiae. Cyclin E2 expressed in mammalian cells associated with CDK2 in a functional kinase complex that was inhibited by both KIP1 and CIP1.[1]

Gudas, J. M., Payton, M., Thukral, S., Chen, E., Bass, M., Robinson, M. O., Coats, S. Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers. Molec. Cell. Biol. 19: 612-622, 1999.