What is the catalog number for Monoclonal Anti- Caveolin-1 antibody?

The catalog number for Monoclonal Anti- Caveolin-1 antibody is BMA1009.

What sizes are available for Monoclonal Anti- Caveolin-1 antibody?

Monoclonal Anti- Caveolin-1 antibody is available in the following size(s): 100 µg.

Is Monoclonal Anti- Caveolin-1 antibody in stock?

Monoclonal Anti- Caveolin-1 antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

Monoclonal Anti- Caveolin-1 antibody

Product Specifications

Background

Caveolins are a family ofHYPERLINK "http://en.wikipedia.org/wiki/Integral_membrane_protein" \o "Integral membrane protein"integral membrane proteinswhich are the principal components ofHYPERLINK "http://en.wikipedia.org/wiki/Caveolae" \o "Caveolae"caveolaemembranes and involved in receptor-independentHYPERLINK "http://en.wikipedia.org/wiki/Endocytosis" \o "Endocytosis"endocytosis.HYPERLINK "http://en.wikipedia.org/wiki/Caveolin" \l "cite_note-pmid8567687-0"[1], they are found in the majority of adherent, mammalian cells, and played an important role during the development of atherosclerosis.HYPERLINK "http://en.wikipedia.org/wiki/Caveolin" \l "cite_note-pmid15768830-4"[2]Caveolin 1 (CAV1) is a member of Caveolin gene family, and most prominently expressed inHYPERLINK "http://en.wikipedia.org/wiki/Endothelium" \o "Endothelium"endothelial, HYPERLINK "http://en.wikipedia.org/wiki/Fibrous_connective_tissue" \o "Fibrous connective tissue"fibrousandHYPERLINK "http://en.wikipedia.org/wiki/Adipose_tissue" \o "Adipose tissue"adiposetissue. It contains 3 exons spanning about 22 kD. It can link the integrin alpha subunit to the tyrosine kinase as a membrane adaptor[3].

Host

Mouse

Reactivity

Human, mouse, rat

Immunogen

A synthetic peptide (conjugated with KLH) corresponding to the C-terminal of mouse Caveolin-1.

Clone

D16

Applications

Western Blot, WB (1:100-200) ; Immunohistochemistry, IHC-P (1:100) ; Immunocytochemistry, ICC (1:100)

Purification

Protein A purified

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol and 0.05% Sodium Azide.

References & Citations

1. Scherer PE, Okamoto T, Chun M, Nishimoto I, Lodish HF, Lisanti MP (January 1996) .HYPERLINK "http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=40192""Identification, sequence, and expression of caveolin-2 defines a caveolin gene family". Proc. Natl. Acad. Sci. U.S.A. 93 (1) : 131–5. 2.Williams TM, Lisanti MP (2004) . "The Caveolin genes: from cell biology to medicine".Ann. Med.36 (8) : 584–95. 3. Yang, G., Truong, L. D., Timme, T. L., Ren, C., Wheeler, T. M., Park, S. H., Nasu, Y., Bangma, C. H., Kattan, M. W., Scardino, P. T., Thompson, T. C. Elevated expression of caveolin is associated with prostate and breast cancer. Clin. Cancer Res. 4: 1873-1880, 1998.