Monoclonal Anti- 14-3-3 beta / alpha antibody

14-3-3 proteins are a family of conserved regulatoryHYPERLINK "http://en.wikipedia.org/wiki/Molecule" \o "Molecule"moleculesexpressed in allHYPERLINK "http://en.wikipedia.org/wiki/Eukaryote" \o "Eukaryote"eukaryoticcells.Theyhave the ability to bind a multitude of functionally diverseHYPERLINK "http://en.wikipedia.org/wiki/Signal_transduction" \o "Signal transduction"signaling proteins, includingHYPERLINK "http://en.wikipedia.org/wiki/Kinase" \o "Kinase"kinases, HYPERLINK "http://en.wikipedia.org/wiki/Phosphatase" \o "Phosphatase"phosphatases, andHYPERLINK "http://en.wikipedia.org/wiki/Transmembrane_receptor" \o "Transmembrane receptor"transmembrane receptors.More than 100 signaling proteins have been reported as 14-3-3 ligands, 14-3-3 b/a is one of them. Theyplay important roles in a wide range of vital regulatory processes, such as mitogenic signal transduction, apoptotic cell death, and cell cycle control.Elevated amounts of 14-3-3 proteins are found in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.[1]

Takahashi H, Iwata T, Kitagawa Y et al. (November 1999) . "Increased levels of epsilon and gamma isoforms of 14-3-3 proteins in cerebrospinal fluid in patients with Creutzfeldt-Jakob disease". Clin. Diagn. Lab. Immunol. 6 (6) : 983–5.