Recombinant Human PDCD5 Protein
Recombinant human PDCD5 is produced by the E.coli system, with the target gene encoding Met1-Tyr125 expressedwith 6x His-tag at the C-terminus.
Product Specifications
Background
Programmed cell death protein 5 is a protein, originally identified as an apoptosis-accelerating protein, that in humans is encoded by the PDCD5 gene.This gene encodes a protein expressed in tumor cells during apoptosis independent of the apoptosis-inducing stimuli. Prior to apoptosis induction, this gene product is distributed in both the nucleus and cytoplasm.Once apoptosis is induced, the level of this protein increases and by relocation from the cytoplasm, it accumulates in the nucleus. Although its exact function is not defined, this protein is thought to play an early and universal role in apoptosis.
Synonyms
PDCD5, programmed cell death 5, TFAR19
Source
E.coli
Applications
SDS-PAGE
Endotoxin
<1 EU/µg by LAL test
Purity
>95%by SDS-PAGE
Buffer
Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 5% Sucrose, 5% Mannitol, 50 mM NaCl, 0.05% Tween 80, pH 8.4.
Reconstitution
Dissolve the lyophilized protein in distilled water (It is not recommended to reconstitute to a concentration<100μg/ml.)
References & Citations
Li G, Ma D, Chen Y (April 2016) . "Cellular functions of programmed cell death 5". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1863 (4) : 572–580. Liu H, Wang Y, Zhang Y, Song Q, Di C, Chen G, Tang J, Ma D (January 1999) . "TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal". Biochemical and Biophysical Research Communications. 254 (1) : 203–210.
Storage Conditions
Shipat 4°C. Upon receipt, aliquot and store at -20°Cor -80°C for long term. Avoid repeated freeze and thaw cycles.
Formulation
Lyophilized
Uniprot Accession Number
O14737
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