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Recombinant Mouse IL-23 Protein

Recombinant mouse IL-23 is produced by the mammalian system, with the target gene encoding Val22-Ala196& Met23-Ser335 expressed.

Product Specifications

Background

Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit.IL-23 is part of the IL-12 family of cytokines.The functional receptor for IL-23 (the IL-23 receptor) consists of a heterodimer between IL-12Rβ1 and IL-23R.IL-23 was discovered in the year 2000 by Robert Kastelein and colleagues at the DNAX research institute using a combination of computational, biochemical and cellular immunology approaches.

Synonyms

IL 23, IL 23 A, IL 23 subunit alpha, IL 23A, IL 23p19, IL23A, IL-23A, IL23P19, Interleukin 23 subunit alpha, Interleukin 23 subunit p19, P19, SGRF

Source

Human Cells

Applications

SDS-PAGE

Endotoxin

<1 EU/µg by LAL test

Purity

>95%by SDS-PAGE

Buffer

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Reconstitution

Dissolve the lyophilized protein in distilled water (It is not recommended to reconstitute to a concentration<100μg/ml.)

References & Citations

Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, et al. (November 2000) . "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12". Immunity. 13 (5) : 715–25. Cauli A, Piga M, Floris A, Mathieu A (2015-10-01) . "Current perspective on the role of the interleukin-23/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis) ". ImmunoTargets and Therapy. 4: 185–90. Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, et al. (June 2002) . "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R". Journal of Immunology. 168 (11) : 5699–708.

Storage Conditions

Shipat 4°C. Upon receipt, aliquot and store at -20°Cor -80°C for long term. Avoid repeated freeze and thaw cycles.

Formulation

Lyophilized

Uniprot Accession Number

Q9EQ14&P43432

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