Recombinant Human IL-15 Protein
Recombinant human IL-15 is produced by the E.coli system, with the target gene encoding Asn49-Ser162 expressed.
Product Specifications
Background
Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2 (IL-2) . Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and the common gamma chain (gamma-C, CD132) . IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus (es) . This cytokine induces the proliferation of natural killer cells, i.e. cells of the innate immune system whose principal role is to kill virally infected cells.
Synonyms
IL15, IL-15, interleukin 15
Source
E.coli
Applications
SDS-PAGE
Endotoxin
<0.01 EU/µg by LAL test
Purity
>95%by SDS-PAGE
Buffer
Lyophilized from a 0.2 μmfiltered solution of 20mM PB,150mM NaCl,4%Mannitol, pH 7.0.
Reconstitution
Dissolve the lyophilized protein in distilled water (It is not recommended to reconstitute to a concentration<100μg/ml.)
References & Citations
Steel JC, Waldmann TA, Morris JC (January 2012) . "Interleukin-15 biology and its therapeutic implications in cancer". Trends Pharmacol Sci. Di Sabatino A, Calarota SA, Vidali F, Macdonald TT, Corazza GR (February 2011) . "Role of IL-15 in immune-mediated and infectious diseases". Cytokine & Growth Factor Reviews. 22 (1) :19–33.
Storage Conditions
Shipat 4°C. Upon receipt, aliquot and store at -20°Cor -80°C for long term. Avoid repeated freeze and thaw cycles.
Formulation
Lyophilized
Uniprot Accession Number
P40933
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