Recombinant Human IL-12 Protein

Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 belongs to the family of interleukin-12. IL-12 family is unique in comprising the only heterodimeric cytokines, which includes IL-12, IL-23, IL-27 and IL-35.Despite sharing many structural features and molecular partners, they mediate surprisingly diverse functional effects.

Interleukin-12 subunit alpha, IL-12A, Cytotoxic lymphocyte maturation factor 35 kDa subunit, CLMF p35, IL-12 subunit p35, NK cell, IL12A , NKSF1 stimulatory factor chain 1

Kaliński P, Hilkens CM, Snijders A, Snijdewint FG, Kapsenberg ML (July 1997) . "IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells". Journal of Immunology. 159 (1) : 28–35. Vignali DA, Kuchroo VK (July 2012) . "IL-12 family cytokines: immunological playmakers". Nature Immunology. 13 (8) : 722–8.