Recombinant Human IL-12 Protein
Recombinant human IL-12 is produced by the mammalian system, with the target gene encoding Arg23-Ser219& Ile23-Ser328 expressed.
Product Specifications
Background
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 belongs to the family of interleukin-12. IL-12 family is unique in comprising the only heterodimeric cytokines, which includes IL-12, IL-23, IL-27 and IL-35.Despite sharing many structural features and molecular partners, they mediate surprisingly diverse functional effects.
Synonyms
Interleukin-12 subunit alpha, IL-12A, Cytotoxic lymphocyte maturation factor 35 kDa subunit, CLMF p35, IL-12 subunit p35, NK cell, IL12A , NKSF1 stimulatory factor chain 1
Source
Human Cells
Applications
SDS-PAGE
Endotoxin
<0.01 EU/µg by LAL test
Purity
>95%by SDS-PAGE
Buffer
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution
Dissolve the lyophilized protein in distilled water (It is not recommended to reconstitute to a concentration<100μg/ml.)
References & Citations
Kaliński P, Hilkens CM, Snijders A, Snijdewint FG, Kapsenberg ML (July 1997) . "IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells". Journal of Immunology. 159 (1) : 28–35. Vignali DA, Kuchroo VK (July 2012) . "IL-12 family cytokines: immunological playmakers". Nature Immunology. 13 (8) : 722–8.
Storage Conditions
Shipat 4°C. Upon receipt, aliquot and store at -20°Cor -80°C for long term. Avoid repeated freeze and thaw cycles.
Formulation
Lyophilized
Uniprot Accession Number
P29459&P29460
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