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Recombinant Human CXCL6 Protein

Recombinant human CXCL6 is produced by the mammalian system, with the target gene encoding Gly38-Asn114 expressed with 6x His-tag at the C-terminus.

Product Specifications

Background

Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2) . As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes.It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2.The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.

Synonyms

C-X-C motif chemokine ligand 6, CXCL6, CKA-3, GCP-2, GCP2, SCYB6

Source

Human Cells

Applications

SDS-PAGE

Endotoxin

<1 EU/µg by LAL test

Purity

>95%by SDS-PAGE

Buffer

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5% Trehalose, 1mM EDTA, pH 7.4.

Reconstitution

Dissolve the lyophilized protein in distilled water (It is not recommended to reconstitute to a concentration<100μg/ml.)

References & Citations

Proost P, Wuyts A, Conings R, Lenaerts J, Billiau A, Opdenakker G, Van Damme J (1993) . "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines". Biochemistry. 32 (38) : 10170–7. Wuyts A, Van Osselaer N, Haelens A, Samson I, Herdewijn P, Ben-Baruch A, Oppenheim J, Proost P, Van Damme J (1997) . "Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties". Biochemistry. 36 (9) : 2716–23. Modi W, Chen Z (1998) . "Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids". Genomics. 47 (1) : 136–9. O'Donovan N, Galvin M, Morgan J (1999) . "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet Cell Genet. 84 (1–2) : 39–42.

Storage Conditions

Shipat 4°C. Upon receipt, aliquot and store at -20°Cor -80°C for long term. Avoid repeated freeze and thaw cycles.

Formulation

Lyophilized

Uniprot Accession Number

P80162

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