Recombinant Human ANG Protein

Angiogenin (ANG) also known as ribonuclease 5 is a small 123 amino acid protein that in humans is encoded by the ANG gene.Angiogenin is a potent stimulator of new blood vessels through the process of angiogenesis. Ang hydrolyzes cellular RNA, resulting in modulated levels of protein synthesis and interacts with DNA causing a promoter-like increase in the expression of rRNA.Ang is associated with cancer and neurological disease through angiogenesis and through activating gene expression that suppresses apoptosis.

Tello-Montoliu A., Patel J.V., Lip G.Y.H. (2006) . "Angiogenin: a review of the pathophysiology and potential clinical applications". Journal of Thrombosis and Haemostasis. 4 (9) : 1864–74. Xu Z, Tsuji T, Riordan J, Hu G (2003) . "Identification and characterization of an angiogenin-binding DNA sequence that stimulate luciferase reporter gene expression". Biochemistry. 42 (1) : 121–128. Li S, Yu W, Hu GF (2012) . "Angiogenin inhibits nuclear translocation of apoptosis inducing factor in a Bcl-2-dependent manner". Journal of Cellular Physiology. 227 (4) : 1639–1644. Steidinger TU, Standaert DG, Yacoubian TA (2011) . "A neuroprotective role for angiogenin in models of Parkinson's disease". Journal of Neurochemistry. 116 (3) : 334–341.