Recombinant Human GDNF Protein
Recombinant human GDNF is produced by the E.coli system, with the target gene encoding Ser78-Ile211 expressed.
Product Specifications
Background
Glial cell line-derived neurotrophic factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene.GDNF is a small protein that potently promotes the survival of many types of neurons.It signals through GFRα receptors, particularly GFRα1. It is also responsible for the determination of spermatogonia into primary spermatocytes, i.e. it is received by RET proto-oncogene (RET) and by forming gradient with SCF it divides the spermatogonia into two cells. As the result there is retention of spermatogonia and formation of spermatocyte.
Synonyms
GDNF, ATF1, ATF2, glial cell derived neurotrophic factor, HFB1-HSCR3, ATF
Source
E.coli
Applications
SDS-PAGE
Endotoxin
<1 EU/µg by LAL test
Purity
>95%by SDS-PAGE
Buffer
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution
Dissolve the lyophilized protein in distilled water (It is not recommended to reconstitute to a concentration<100μg/ml.)
References & Citations
Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F (May 1993) . "GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons". Science. 260 (5111) . New York, N.Y.:1130–1132.
Storage Conditions
Shipat 4°C. Upon receipt, aliquot and store at -20°Cor -80°C for long term. Avoid repeated freeze and thaw cycles.
Formulation
Lyophilized
Uniprot Accession Number
P39905
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