Recombinant Human IL-8 Protein

Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cellsand endothelial cells. Endothelial cells store IL-8 in their storage vesicles, the Weibel–Palade bodies.In humans, the interleukin-8 protein is encoded by the CXCL8 gene.IL-8 is initially produced as a precursor peptide of 99 amino acids which then undergoes cleavage to create several active IL-8 isoforms.In culture, a 72 amino acid peptide is the major form secreted by macrophages.

CXCL8, chemokine (C-X-C motif) ligand 8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, IL8, C-X-C motif chemokine ligand 8, Interleukin-8, SCYB8

Hedges JC, Singer CA, Gerthoffer WT (July 2000) . "Mitogen-activated protein kinases regulate cytokine gene expression in human airway myocytes". American Journal of Respiratory Cell and Molecular Biology. 23 (1) : 86–94. CiteSeerX 10.1.1.326.6212. Wolff B, Burns AR, Middleton J, Rot A (November 1998) . "Endothelial cell "memory" of inflammatory stimulation: human venular endothelial cells store interleukin 8 in Weibel-Palade bodies". The Journal of Experimental Medicine. 188 (9) : 1757–1762. Utgaard JO, Jahnsen FL, Bakka A, Brandtzaeg P, Haraldsen G (November 1998) . "Rapid secretion of prestored interleukin 8 from Weibel-Palade bodies of microvascular endothelial cells".The Journal of Experimental Medicine. 188 (9) : 1751–1756.