Recombinant Human CD11C Protein

Recombinant human CD11C protein with his tag.

Product Specifications

Background

CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c.CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4) . The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.

Synonyms

CD11C, SLEB6, ITGAX, integrin subunit alpha X

Source

HEK293 Cells

Applications

SDS-PAGE

Endotoxin

<1.0 EU per μg of the protein as determined by the LAL method

Purity

>90% by SDS-PAGE

Buffer

Each vial Lyophilized from 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

References & Citations

"Entrez Gene: ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) ". Dyer KD, Garcia-Crespo KE, Killoran KE, Rosenberg HF (2011) . "Antigen profiles for the quantitative assessment of eosinophils in mouse tissues by flow cytometry". Journal of Immunological Methods. 369 (1–2) : 91–7.