Recombinant Human RBP-4 Protein

Recombinant human RBP-4 protein.

Product Specifications

Background

Retinol binding protein 4, plasma, also known as RBP4, is proteinthat in Mouse is encoded by the RBP4 gene. The RBP4 gene resides just centromeric of the cluster of CYP2C genes on 10q24. It belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. RBP4 has recently been described as an adipokine that contributes to insulin resistance in the AG4KO mouse model. It is secreted by adipocytes, and can act as a signal to other cells, when there is a decrease in plasma glucose concentration.

Synonyms

Retinol-binding protein 4, RBP4, RBP-4, Plasma retinol-binding protein, PRBP, RBP, PRO2222

Source

E. Coli

Applications

ELISA

Purity

>90%by SDS-PAGE

Buffer

Each vial contains10mM Tris-Hcl, pH 7.4.

References & Citations

1.Rask L, Anundi H, Fohlman J, Peterson PA (1987) . "The complete amino acid sequence ofHumanserum retinol-binding protein". Upsala Journal of Medical Sciences 92 (2) : 115–46. 2.Gray, I. C., Nobile, C., Muresu, R., Ford, S., Spurr, N. K. A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24. Genomics 28: 328-332, 1995. 3.Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB (2005) . "Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes". Nature 436 (7049) : 356–62. 4.Herman MA, Kahn BB (2006) . "Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony". J. Clin. Invest. 116 (7) : 1767–75.