Recombinant Human Interleukin-1 alpha, IL1A Protein

Interleukin-1 alpha (IL-1α) is a protein of the interleukin-1 family that in humans is encoded by the IL1A gene which spans 10.2 kb and has 7 exons. It is 1 of 2 structurally distinct forms of IL1, the other being IL1B, this two proteins are synthesized by a variety of cell types, including activated macrophages, keratinocytes, stimulated B lymphocytes, and fibroblasts, and are potent mediators of inflammation and immunity. IL1A may play a role in the genesis of inflammation by augmenting the transcription of proinflammatory genes, a mechanism not affected by extracellular inhibitors. IL1A has been administered to patients during receiving autologous bone marrow transplantation.

1.Nicklin MJ, Weith A, Duff GW (Jun 1994) . "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes". Genomics 19 (2) : 382–4. 2.Lord, P. C. W., Wilmoth, L. M. G., Mizel, S. B., McCall, C. E. Expression of interleukin-1 alpha and beta genes by human blood polymorphonuclear leukocytes. J. Clin. Invest. 87: 1312-1321, 1991. 3.Furutani, Y., Notake, M., Fukui, T., Ohue, M., Nomura, H., Yamada, M., Nakamura, S. Complete nucleotide sequence of the gene for human interleukin 1 alpha. Nucleic Acids Res. 14: 3167-3179, 1986. Note: Erratum: Nucleic Acids Res. 14: 5124 only, 1986. 4.Werman, A., Werman-Venkert, R., White, R., Lee, J.-K., Werman, B., Krelin, Y., Voronov, E., Dinarello, C. A., Apte, R. N. The precursor form of IL-1-alpha is an intracine proinflammatory activator of transcription. Proc. Nat. Acad. Sci. 101: 2434-2439, 2004. 5.Smith JW, Longo DL, Alvord WG, Janik JE, Sharfman WH, Gause BL, Curti BD, Creekmore SP, Holmlund JT, Fenton RG (March 1993) . "The effects of treatment with interleukin-1 alpha on platelet recovery after high-dose carboplatin". N. Engl. J. Med. 328 (11) : 756–61.