Recombinant Human Insulin-like growth factors-1, IGF1Protein

Recombinant human IGF1 protein with molecular weight of 32 kDa.

Product Specifications

Background

Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein that in humans is encoded by the IGF1 gene. IGF-1 has also been referred to as a "sulfation factor" and its effects were termed "nonsuppressible insulin-like activity" (NSILA) in the 1970s. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin, is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7,649 Dalton.

Synonyms

IBP1, IGF 1, IGF I, IGF-1, IGF IA, IGF IB, IGF1, IGFI, IGFIA, Insulin like growth factor 1 (somatomedin C), Full=Insulin-like growth factor I, Insulin Like Growth Factor 1, Insulin like growth factor IA, Insulin like growth factor IB, Mechano growth factor, MGF, Mechano growth factor, MGF, Somatomedia C, Somatomedin C, IGF-I.

Source

E. Coli

Applications

Western Blot, WB; ELISA

Purity

> 90% by SDS-PAGE

Buffer

Each vial contains 10 mM PBS, pH 7.4±0.2 with 0.1% SKL as the preservative.

References & Citations

1. Höppener JW, de Pagter-Holthuizen P, Geurts van Kessel AH, Jansen M, Kittur SD, Antonarakis SE, Lips CJ, Sussenbach JS (1985) . "The human gene encoding insulin-like growth factor I is located on chromosome 12". Hum. Genet. 69 (2) : 157–60. 2. Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL (1983) . "Sequence of cDNA encoding human insulin-like growth factor I precursor". Nature. 306 (5943) : 609–11. 3. Salmon WD, Daughaday WH (1957) . "A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro". J Lab Clin Med. 49 (6) : 825–36. 4. Keating GM (2008) . "Mecasermin". BioDrugs. 22 (3) : 177–88. 5. Rinderknecht E, Humbel RE (1978) . "The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin". J Biol Chem. 253 (8) : 2769–2776..