Recombinant Human Islet cells Antigen, ICA230 Protein

Recombinant human Islet cells Antigen 230 protein with molecular weight of 53 kDa.

Product Specifications

Background

Islet cell autoantigen 1 is a protein that in humans is encoded by the ICA1 gene.This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Synonyms

Islet cells antigen, Islet cells antigen 230, ICA230, ICA 230.

Source

E. Coli

Applications

ELISA

Purity

>85% by SDS-PAGE

Buffer

Each vial contains Tris-HCl, pH 7.4±0.2 with 0.02% NaN3.

References & Citations

Miyazaki I, Gaedigk R, Hui MF, Cheung RK, Morkowski J, Rajotte RV, Dosch HM (Nov 1994) . "Cloning of human and rat p69 cDNA, a candidate autoimmune target in type 1 diabetes". Biochim Biophys Acta. 1227 (1–2) : 101–4. Mally MI, Cirulli V, Hayek A, Otonkoski T (Sep 1996) . "ICA69 is expressed equally in the human endocrine and exocrine pancreas". Diabetologia. 39 (4) : 474–80.