Recombinant Human HSP90 alpha (cytosolic) member A1, HSP90AA1Protein

Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation.In a functional proteomic screen for proteins required for invasion, extracellular heat shock protein 90 alpha (Hsp90α) was identified and shown to activate matrix metalloproteinase 2 (MMP-2) . The mechanism of MMP-2 activation by Hsp90α is unknown. Intracellular Hsp90α commonly functions with a complex of co-chaperones, leading to our hypothesis that Hsp90α functions similarly outside of the cell. An increase in Hsp-90a concentrations in patients with arterial hypertension may be a compensatory mechanism for the impaired bioavailability of nitric oxide.

HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2, HEL-S-65p, Heat shock protein 90kDa alpha, heat shock protein 90kDa alpha family class A member 1, heat shock protein 90 alpha family class A member 1, Hsp103

Skórzyńska-Dziduszko KE, Olszewska A, Prendecka M, Małecka-Massalska T.Serum Heat Shock Protein 90 Alpha: A New Marker of Hypertension-Induced Endothelial Injury? Adv Clin Exp Med. 2016 Mar-Apr;25 (2) :255-61. Sims JD, McCready J, Jay DG. Extracellular heat shock protein (Hsp) 70 and Hsp90α assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasion. PLoS One. 2011 Apr 14;6 (4) :e18848.