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Recombinant Human Brain-type creatine kinase, CK-BB protein

Recombinant Brain-type creatine kinase, CK-BB Protein.

Product Specifications

Background

Brain-type creatine kinase also known as CK-BB is a creatine kinase that in humans is encoded by the CKB gene.The protein encoded by this gene, CK-BB, consists of a homodimer of two identical brain-type CK-B subunits. BB-CK is a cytoplasmic enzyme involved in cellular energy homeostasis, with certain fractions of the enzyme being bound to cell membranes, ATPases, and a variety of ATP-requiring enzymes in the cell. The encoded CK-BB and CK-MB proteins are members of the ATP:guanido phosphotransferase protein family. Ectopic expression (CKBE) of the B (brain) type of creatine kinase (CK-BB) in red cells and platelets is a rare, benign anomaly detected during a newborn screening program for Duchenne muscular dystrophy.

Synonyms

B-CK, BB-CK, BCK, brain creatine kinase, CKBB, CKb, creatine kinase B, creatine kinase brain, creatine kinase BB, Creatine Kinase brain type, Epididymis luminal protein 211, HEL 211.

Source

E. Coli

Applications

ELISA

Purity

>80% by SDS-PAGE

Buffer

Each vial contains20 mM Tris-HCl pH8.0.

References & Citations

Mariman EC, Schepens JT, Wieringa B (August 1989) . "Complete nucleotide sequence of the human creatine kinase B gene". Nucleic Acids Res. 17 (15) : 6385. Kotz R, Leber H, Ramach W, Arbes H, Wolf A (July 1977) . "[Clinical observations on the use of high-dose methotrexate treatment in osteogenic sarcoma (author's transl) ]". Wien. Klin. Wochenschr. (in German) . 89 (14) : 474–9. Wienker TF, Ulferts A, Ott J, Bender K, Scheuerbrandt G, Arnold H, Ropers HH (1985) . "A dominant mutation causing ectopic expression of the creatine kinase B gene maps on chromosome 14". Cytogenet. Cell Genet. 40: 776.

Storage Conditions

Shipat 4°C. Upon receipt, aliquot and store at -20°C for long term. Avoid repeated freeze and thaw cycles.

Formulation

Liquid

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