C-Peptide Protein (Active)

Recombinant full length human C-Peptide protein.

Product Specifications

Background

Connecting peptide, or C-peptide, is a short 31-amino-acid protein that connects insulin's A-chain to its B-chain in the proinsulin molecule. C-peptide has been shown to bind to the surface of a number of cell types such as neuronal, endothelial, fibroblast and renal tubular, at nanomolar concentrations to a receptor that is likely G-protein-coupled. It has been found to exert beneficial effects in many tissues affected by diabetic microvascular complications, including the kidneys. C-peptide at physiological concentrations effectively reduces diabetes-induced glomerular hyperfiltration via constriction of the afferent arteriole, dilation of the efferent arteriole, and inhibition of tubular reabsorption in experimental models of type 1 diabetes.

Synonyms

C-peptide, Connecting peptide

Source

E. coli

Applications

ELISA

Purity

>95% by HPLC & SDS-PAGE

Buffer

Each vial contains 10mM PBS (pH7.5) without preservative.

References & Citations

Nordquist L, Wahren J (2009) . "C-Peptide: the missing link in diabetic nephropathy". Rev Diabet Stud 6 (3) : 203–10.

Storage Conditions

Shipat 4°C. Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.

Formulation

Liquid