Seriniquinone
Seriniquinone, a selective anti-melanoma agent that targets Dermcidin, induces cell death by autophagocytosis. Seriniquinone is a metabolite produced by a rare marine bacterium of the genus Serinicoccus[1][2].
Product Specifications
CAS Number
[22200-69-7]
UNSPSC
12352005
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/seriniquinone.html
Purity
98.39
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C2C(C3=O)=C(C(C4=C3C=CC=C4)=O)S1)C5=C(C=CC=C5)C2=O
Molecular Formula
C20H8O4S
Molecular Weight
344.34
References & Citations
[1]Lynnie Trzoss, et al. Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin. Proc Natl Acad Sci U S A. 2014 Oct 14;111 (41) :14687-92.|[2]Amanda S Hirata, et al. Seriniquinones as Therapeutic Leads for Treatment of BRAF and NRAS Mutant Melanomas. Molecules. 2021 Dec 4;26 (23) :7362.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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