LAS195319
Product Specifications
UNSPSC Description
LAS195319 is an orally active and potent inhibitor against PI3Kδ with an IC50 value of 0.5 nM. LAS195319 is also a highly selective inhibitor against an extensive panel of proteins, lipid kinases and GPCRs. LAS195319 causes an inhibition of neutrophil and eosinophil infiltration. LAS195319 is promising for research of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD)[1].
Target Antigen
G Protein-coupled Receptor Kinase (GRK); Lipase; PI3K
Type
Reference compound
Related Pathways
GPCR/G Protein;Metabolic Enzyme/Protease;PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/las195319.html
Smiles
O=S(N)(NC1=CC2=C(C(C3=CNC4=NC=NC(N[C@H](C(N(C5=CC=CC=C5)C6=O)=NN7C6=C(C)C=C7)C)=C43)=C1)C=CN2)=O
Molecular Weight
594.65
References & Citations
[1]Erra M, et al. Discovery of a Novel Inhaled PI3Kδ Inhibitor for the Treatment of Respiratory Diseases. J Med Chem. 2018 Nov 8;61(21):9551-9567.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-123862/LAS195319-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-123862/
Clinical Information
No Development Reported
CAS Number
1605328-04-8
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