LAS195319
LAS195319 is an orally active and potent inhibitor against PI3Kδ with an IC50 value of 0.5 nM. LAS195319 is also a highly selective inhibitor against an extensive panel of proteins, lipid kinases and GPCRs. LAS195319 causes an inhibition of neutrophil and eosinophil infiltration. LAS195319 is promising for research of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD) [1].
Product Specifications
CAS Number
[1605328-04-8]
UNSPSC
12352005
Target
G Protein-coupled Receptor Kinase (GRK) ; Lipase; PI3K
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/las195319.html
Smiles
O=S(N)(NC1=CC2=C(C(C3=CNC4=NC=NC(N[C@H](C(N(C5=CC=CC=C5)C6=O)=NN7C6=C(C)C=C7)C)=C43)=C1)C=CN2)=O
Molecular Formula
C29H26N10O3S
Molecular Weight
594.65
References & Citations
[1]Erra M, et al. Discovery of a Novel Inhaled PI3Kδ Inhibitor for the Treatment of Respiratory Diseases. J Med Chem. 2018 Nov 8;61 (21) :9551-9567.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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