Inosine-5'-diphosphate-15N4 (dilithium)

Inosine-5'-diphosphate-15N4 dilithium (IDP-15N4 dilithium) is 15N labeled Inosine-5'-diphosphate dilithium. Inosine-5'-diphosphate (IDP) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate has a superior bond capacity on GDP-binding pocket of NM23-H2 (KD: 5.0 μM) . Inosine-5'-diphosphate abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research[1][2][3][4].

Product Specifications

Product Name Alternative

IDP-15N4 (dilithium) ; Inosine-5'-diphosphoric acid-15N4 (disodium)

UNSPSC

12352005

Target

Apoptosis; c-Myc; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Others

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/inosine-5-diphosphoric-acid-15n4-dilithium.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=C([15N]([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(O[Li])(O[Li])=O)(O)=O)O3)C=[15N]2)[15NH]C=[15N]1

Molecular Formula

C10H12Li2 15N4O11P2

Molecular Weight

444.03

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Sengupta P, et al. Inosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding. Biochim Biophys Acta Gen Subj. 2020 Sep;1864 (9) :129649. |[3]Sokolov I K, et al. Adaptogenic effect of riboxin[J]. Pharmaceutical Chemistry Journal, 1980, 14 (1) : 34-39.|[4]Veveris M, et al. Experimental study of the antiarrhythmic effect of riboxin. Farmakol. Neirotropnykh Sredstv (1978), 119-24.