Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

SAG

SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo[1][2][3].

Product Specifications

CAS Number

912545-86-9

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Smo

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SAG.html

Concentration

10mM

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C(Cl)C2=CC=CC=C2S1)N([C@H]3CC[C@H](NC)CC3)CC4=CC=CC(C5=CC=NC=C5)=C4

Molecular Formula

C28H28ClN3OS

Molecular Weight

490.06

Precautions

H302, H315, H319, H335

References & Citations

[1]Chen JK, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002 Oct 29;99 (22) :14071-6.|[2]Stanton BZ, et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar;5 (3) :154-6.|[3]Lee S, et al. Combining Smoothened Agonist (SAG) and NEL-like protein-1 (NELL-1) Enhances Bone Healing. Plast Reconstr Surg. 2017 Feb 13|[4]Fish EW, et al. Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice. Birth Defects Res A Clin Mol Teratol. 2016 Nov 1|[5]Guerrini G, et, al. Inhibition of smoothened in breast cancer cells reduces CAXII expression and cell migration. J Cell Physiol. 2018 Dec; 233 (12) : 9799-9811.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Adv Sci (Weinh) . 2025 Jan 9:e2411675.|Biochem Pharmacol. 2021 Aug:190:114593.|Biomedicines. 2022 Apr 18;10 (4) :928. |bioRxiv. 2025 July 21.|bioRxiv. 2025 March 25.|Cell Commun Signal. 2024 Feb 15;22 (1) :123.|Cell Rep Methods. 2024 May 8:100777.|Cell Rep. 2020 Apr.|Cell Res. 2022 Mar;32 (3) :288-301.|Cell Stem Cell. 2025 Jul 3;32 (7) :1071-1086.e8.|Development. 2018 Sep 20;145 (18) . pii: dev164830.|Ecotoxicol Environ Saf. 2025 Aug 6:303:118813.|Exp Eye Res. 2025 May 21:110440.|Glia. 2021 Jul;69 (7) :1782-1798.|iScience. 2022 Dec 26;26 (1) :105898.|iScience. 2024 Feb 5;27 (3) :109111.|J Biomed Mater Res A. 2025 Oct;113 (10) :e38001.|J Cell Mol Med. 2022 Jun;26 (11) :3213-3222.|J Pathol. 2025 Nov 6.|J Pharm Biomed Anal. 2017 Aug 5:142:201-209.|J Tradit Complement Med. 2025 Jun 14.|Mol Brain. 2021 Jul 19;14 (1) :116.|Molecules. 2017 Dec 31;23 (1) . pii: E85.|Patent. US20240247230A1.|Research Square Preprint. 2021 Sep.|Sci Adv. 2023 Jun 16;9 (24) :eadf6927.|Tissue Cell. 2024 Nov 28:92:102643.|Toxins. 2021 Aug 22;13 (8) :585.|University of Bonn. 2021 May 21.|Cancer Sci. 2021 Oct;112 (10) :4176-4186.|Drug Dev Res. 2019 Nov;80 (7) :992-999.|Sci Adv. 2025 Jan 10;11 (2) :eads5434.|Sci Rep. 2025 Oct 14;15 (1) :35928.|Nat Commun. 2024 Feb 2;15 (1) :987.|UNIVERSIDAD DE CONCEPCIÓN. 2023 Apr.

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

INO80B Protein Vector (Human) (pPM-C-HA)
PV021563 500 ng

INO80B Protein Vector (Human) (pPM-C-HA)

Sign In for Pricing
View Details
Carboxypeptidase A3, Mast Cell (CPA3) BioAssayTM ELISA Kit (Mouse)
023917 96 Tests

Carboxypeptidase A3, Mast Cell (CPA3) BioAssayTM ELISA Kit (Mouse)

Sign In for Pricing
View Details
Protein Wnt-2b, Recombinant, Human, aa1-391, His-SUMO-Tag
586032-01 20 µg

Protein Wnt-2b, Recombinant, Human, aa1-391, His-SUMO-Tag

Sign In for Pricing
View Details
Protein Wnt-2b, Recombinant, Human, aa1-391, His-SUMO-Tag
586032-02 100 µg

Protein Wnt-2b, Recombinant, Human, aa1-391, His-SUMO-Tag

Sign In for Pricing
View Details
HTR1F siRNA (Mouse)
orb1847324-01 15 nmol

HTR1F siRNA (Mouse)

Sign In for Pricing
View Details
HTR1F siRNA (Mouse)
orb1847324-02 30 nmol

HTR1F siRNA (Mouse)

Sign In for Pricing
View Details