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(Rac) -OSMI-1

(Rac) -OSMI-1 is the racemate of OSMI-1. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans[1][2].

Product Specifications

CAS Number

2748153-92-4

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Acyltransferase; OGT

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/rac-osmi-1.html

Purity

96.51

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N(CC1=CC=CS1)CC2=CC=CO2)C(NS(C3=CC(C=C4)=C(C=C3)NC4=O)(=O)=O)C5=CC=CC=C5OC

Molecular Formula

C28H25N3O6S2

Molecular Weight

563.64

Precautions

H302, H315, H319

References & Citations

[1]Ortiz-Meoz RF, et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 2015 Jun 19;10 (6) :1392-7.|[2]Liu Y, et al. Discovery of a Low Toxicity O-GlcNAc Transferase (OGT) Inhibitor by Structure-based Virtual Screening of Natural Products. Sci Rep. 2017 Sep 26;7 (1) :12334.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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