What is the catalog number for Recombinant human 14-3-3 epsilon protein?

The catalog number for Recombinant human 14-3-3 epsilon protein is YWE0701-500.

What sizes are available for Recombinant human 14-3-3 epsilon protein?

Recombinant human 14-3-3 epsilon protein is available in the following size(s): 500 µg.

Is Recombinant human 14-3-3 epsilon protein in stock?

Recombinant human 14-3-3 epsilon protein is currently made to order / not held in immediate stock. Contact us for lead time.

Recombinant human 14-3-3 epsilon protein

The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. The 14-3-3 epsilon, a subtype of the 14-3-3 family of proteins, was thought to be brain and neuron-specific. It has been shown to interact with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Recombinant human 14-3-3 epsilon was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

YWHAE, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon, 14-3-3E, HEL2, KCIP-1, MDCR, MDS

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

29 kDa (255aa) confirmed by MALDI-TOF

Additionnal Information

1433 epsilon, Tyrosine 3-monooxygenase/ tryptophan 5-monooxygenase activation protein epsilon polypeptide, YWHAE, MDS, MDCR, KCIP-1, FLJ45465, 14-3-3 epsilon, Tyrosine 3/tryptophan 5-monooxygenase activation protein, epsilon polypeptide, Tyrosine 3-monooxygenase/ tryptophan 5-monooxygenase activation protein, epsilon polypeptide 14 3 3 E, 14 3 3E, KCIP 1, KCIP1, Mitochondrial import stimulation factor L subunit, Protein kinase C inhibitor protein1, Tyrosine 3/tryptophan 5 monooxygenase activation protein epsilon polypeptide., YWE0701-10 µg, YWE0701-20 µg, YWE0701-50 µg, YWE0701-100 µg, YWE0701-250 µg, YWE0701-500 µg, YWE0701-1 mg, YWE0701-10, YWE0701-20, YWE0701-50, YWE0701-100, YWE0701-250, YWE0701-500, YWE0701-1

References & Citations

Oriente F, et al. (2005) J Biol Chem. 280 (49) :40642-9.; ; Conklin D, et al. (1995) PNAS. 92 (17) :7892-6;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 7.5)

Scientific Category

Signal Transduction

NCBI Accession Number

NP_006752.1

Uniprot Accession Number

P62258

Species

Human

AA Sequence

MDDREDLVYQ AKLAEQAERY DEMVESMKKV AGMDVELTVE ERNLLSVAYK NVIGARRASW RIISSIEQKE ENKGGEDKLK MIREYRQMVE TELKLICCDI LDVLDKHLIP AANTGESKVF YYKMKGDYHR YLAEFATGND RKEAAENSLV AYKAASDIAM TELPPTHPIR LGLALNFSVF YYEILNSPDR ACRLAKAAFD DAIAELDTLS EESYKDSTLI MQLLRDNLTL WTSDMQGDGE EQNKEALQDV EDENQ