Recombinant human Syntaphilin protein

Syntaphilin is a neuron-specific protein initially characterized as a binding partner of syntaxin-1. The protein competes with SNAP-25 for binding to syntaxin-1 and prevents the formation of the SNARE core complex, thereby controlling free syntaxin-1 availability for the assembly of the SNARE complex and potentially regulating synaptic vesicle exocytosis. Recombinant Syntaphilin protein was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

SNPH, Syntaphilin, KIAA0374.

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

48.2 KDa (444aa)

Additionnal Information

Syntaphilin, SNPH, Syntaphilin, KIAA0374., SNP0902-10 µg, SNP0902-20 µg, SNP0902-50 µg, SNP0902-100 µg, SNP0902-250 µg, SNP0902-500 µg, SNP0902-1 mg, SNP0902-10, SNP0902-20, SNP0902-50, SNP0902-100, SNP0902-250, SNP0902-500, SNP0902-1

References & Citations

Lao G., et al. Neuron. 2000 25 (1), 191-201.; ; Boczan., et al. J Biol Chem. 2004 279 (18), 18911-9.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10 % glycerol

Scientific Category

Neuroscience

NCBI Accession Number

NP_055538.2

Uniprot Accession Number

O15079

Species

Human

AA Sequence

MAMSLPGSRR TSAGSRRRTS PPVSVRDAYG TSSLSSSSNS GSYKGSDSSP TPRRSMKYTL CSDNHGIKPP TPEQYLTPLQ QKEVCIRHLK ARLKDTQDRL QDRDTEIDDL KTQLSRMQED WIEEECHRVE AQLALKEARK EIKQLKQVID TVKNNLIDKD KGLQKYFVDI NIQNKKLETL LHSMEVAQNG MAKEDGTGES AGGSPARSLT RSSTYTKLSD PAVCGDRQPG DPSSGSAEDG ADSGFAAADD TLSRTDALEA SSLLSSGVDC GTEETSLHSS FGLGPRFPAS NTYEKLLCGM EAGVQASCMQ ERAIQTDFVQ YQPDLDTILE KVTQAQVCGT DPESGDRCPE LDAHPSGPRD PNSAVVVTVG DELEAPEPIT RGPTPQRPGA NPNPGQSVSV VCPMEEEEEA AVAEKEPKSY WSRH