Recombinant human Syntaphilin protein
Syntaphilin is a neuron-specific protein initially characterized as a binding partner of syntaxin-1. The protein competes with SNAP-25 for binding to syntaxin-1 and prevents the formation of the SNARE core complex, thereby controlling free syntaxin-1 availability for the assembly of the SNARE complex and potentially regulating synaptic vesicle exocytosis. Recombinant Syntaphilin protein was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
SNPH, Syntaphilin, KIAA0374.
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
48.2 KDa (444aa)
Additionnal Information
References & Citations
Lao G., et al. Neuron. 2000 25 (1), 191-201.; ; Boczan., et al. J Biol Chem. 2004 279 (18), 18911-9.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10 % glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_055538.2
Uniprot Accession Number
O15079
Species
Human
AA Sequence
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