Recombinant human gamma-Synuclein protein

Gamma-synuclein (Originally known as a breast cancer specific gene product, BCSG1) is an acidic neuronal protein of 127 amino acids. The protein coding region of gamma-synuclein was amplified by RT-PCR and cloned into an E. coli expression vector. gamma-synuclein was overexpressed in E. coli and purified to apparent homogeneity by taking advantage of the thermosolubility of the protein and by using conventional column chromatography techniques.

Product Specifications

Product Name Alternative

Synuclein gamma, SNCG, BCSG1, SR, Persyn, PRSN, Synoretin, Breast cancer-specific gene 1, ɣ-synuclein

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by BCA assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

13.3 kDa (127aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Additionnal Information

G-Synuclein, Synuclein gamma (breast cancer-specific protein 1), SNCG, BCSG1, PERSYN, PRSN, gamma-Synuclein, Persyn, Breast cancer-specific gene 1 protein, Synoretin, SR, gamma-synuclein, gamma synuclein, Synuclein, gamma (breast cancer-specific protein 1) BCSG 1, Breast cancer specific gene 1, Breast cancer specific gene 1 protein, Breast cancer specific protein 1, Gamma synuclein, SNCG protein, SR, Synuclein gamma, SNG2001-10 µg, SNG2001-20 µg, SNG2001-50 µg, SNG2001-100 µg, SNG2001-250 µg, SNG2001-500 µg, SNG2001-1 mg, SNG2001-10, SNG2001-20, SNG2001-50, SNG2001-100, SNG2001-250, SNG2001-500, SNG2001-1

References & Citations

Ji H., et al. (1997) Cancer Res. 57 (4) :759-64.

Other References

Ahn KJ, et al. Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein. (J Neurochem. 2006) {https://pubmed.ncbi.nlm.nih.gov/16524375/}; ; Park JY, et al. Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinsons disease. (Glia. 2008) {https://pubmed.ncbi.nlm.nih.gov/18449945/}; ; Kim KS, et al. Regulation of Weibel-Palade body exocytosis by alpha-synuclein in endothelial cells. (J Biol Chem. 2010) {https://pubmed.ncbi.nlm.nih.gov/20448034/}; ; Kawakami F, et al. Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β. (FEBS J. 2011) {https://pubmed.ncbi.nlm.nih.gov/21985244/}; ; Konno M, et al. Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy. (Mol Neurodegener. 2012) {https://pubmed.ncbi.nlm.nih.gov/22892036/}; ; Førland MG, et al. Validation of a new assay for α-synuclein detection in cerebrospinal fluid. (Clin Chem Lab Med. 2017) {https://pubmed.ncbi.nlm.nih.gov/27474841/}