Recombinant human alpha-Synuclein (1-95aa) protein

A deletion mutant of alpha-synuclein (amino acids 1-95), which contains the N-terminal amphipathic domain and NAC region. alpha-synuclein 1-95 was overexpressed in E. coli and the recombinant protein was purified to apparent homogeneity by using conventional column chromatography techniques.

Product Specifications

Product Name Alternative

SNCA, NACP, PARK1, PARK4, PD1, α-synuclein Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Parkinson disease 4, autosomal dominant Lewy body

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by BCA assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

9.3 kDa (95aa) confirmed by MALDI-TOF

Additionnal Information

A-Synuclein (195aa), SNCA, NACP, PARK1, alpha-Synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Alpha synuclein, Alpha-synuclein isoform NACP140, alphaSYN, MGC105443, MGC110988, MGC127560, MGC64356, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid, precursor of PARK 1, PARK 4, PARK4, Parkinson disease familial 1, PD 1, PD1, Synuclein alpha, SNA4002-10 µg, SNA4002-20 µg, SNA4002-50 µg, SNA4002-100 µg, SNA4002-250 µg, SNA4002-500 µg, SNA4002-1 mg, SNA4002-10, SNA4002-20, SNA4002-50, SNA4002-100, SNA4002-250, SNA4002-500, SNA4002-1

References & Citations

Ueda K., et al. (1993) Proc. Natl. Acad. Sci. 90, 11282-11286. ; ; Jakes., et al. (1994) FEBS Letters 345, 27-32

Other References

Park JY, et al. Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinsons disease. (Glia. 2008) {https://pubmed.ncbi.nlm.nih.gov/18449945/}; ; Kawakami F, et al. Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β. (FEBS J. 2011) {https://pubmed.ncbi.nlm.nih.gov/21985244/}