What is the catalog number for Recombinant human c-kit Ligand/SCF protein?

The catalog number for Recombinant human c-kit Ligand/SCF protein is SCF0601-500.

What sizes are available for Recombinant human c-kit Ligand/SCF protein?

Recombinant human c-kit Ligand/SCF protein is available in the following size(s): 500 µg.

Is Recombinant human c-kit Ligand/SCF protein in stock?

Recombinant human c-kit Ligand/SCF protein is currently made to order / not held in immediate stock. Contact us for lead time.

Recombinant human c-kit Ligand/SCF protein

Stem Cell Factor (SCF) is a glycoprotein that plays a key role in hematopoiesis acting both as a positive and negative regulator, often in synergy with other cytokines. SCF binds to and activates the SCF receptor (SCFR), a receptor tyrosine kinase. SCF stimulates the proliferation of mast cells and is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. It also mediates cell-cell adhesion and acts synergistically with other cytokine. Recombinant human SCF was expressed in E. coli and purified by conventional column chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.

Product Specifications

Product Name Alternative

Kit ligand, KITLG, Mast cell growth factor, MGF, Stem cell factor, SCF, c-Kit ligand, steel factor, SF, Kitl, KL-1, Familial progressive hyperpigmentation 2, FPH2, SLF, DFNA69

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

18.5 kDa (165aa) confirmed by MALDI-TOF

Additionnal Information

SCF, Stem cell factor, KITLG, MGF, SCF, C-kit ligand, Stem cell factor, SCF, Mast cell growth factor, MGF, Kit ligand, Stem cell factor, SF, Kitl, KL-1, FPH2, steel factor, familial progressive hyperpigmentation 2, SCF0601-10 µg, SCF0601-20 µg, SCF0601-50 µg, SCF0601-100 µg, SCF0601-250 µg, SCF0601-500 µg, SCF0601-1 mg, SCF0601-10, SCF0601-20, SCF0601-50, SCF0601-100, SCF0601-250, SCF0601-500, SCF0601-1

References & Citations

Zhang Z., et al. (2000) . Proc. Natl. Acad. Sci. u.S.A. 97, 7732.; ; Okada S , et al. (1992) . Nippon Rinsho , 50, 1872.;

Other References

Lee SH, et al. Involvement of MITF-A, an alternative isoform of mi transcription factor, on the expression of tryptase gene in human mast cells. (Exp Mol Med. 2010) {https://pubmed.ncbi.nlm.nih.gov/20513998/}; ; Takahashi M, et al. CD133 is a positive marker for a distinct class of primitive human cord blood-derived CD34-negative hematopoietic stem cells. (Leukemia. 2014) {https://pubmed.ncbi.nlm.nih.gov/24189293/}; ; Yamada T, et al. CXCL12 regulates differentiation of human immature melanocyte precursors as well as their migration. (Arch Dermatol Res. 2019) {https://pubmed.ncbi.nlm.nih.gov/30483878/}

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4)

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_000890.1

Uniprot Accession Number

P21583

Species

Human

AA Sequence

MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTDL LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVA