Recombinant human RXR alpha/RXRA protein
The retinoid X receptor (RXR) is a pleiotropic nuclear receptor transcription factor that interacts with a variety of nuclear receptor dimeric partner. RXR binds cognate response elements as a homodimer in the presence of its ligand, 9-cis retinoic acid, or as a heterodimer with other members of the nuclear hormone receptor superfamily including retinoic acid receptors (RAR), thyroid hormone receptors (TR), vitamin D receptors and peroxisome proliferators-activated receptors (PPAR) . The RXR family includes three difference isoforms ; RXR alpha, beta, gamma. Human RXR alpha gene is localized on 9q34. 9 and encodes two major isoforms (RXR alpha1, RXR alpha2) . The DNA binding domain of RXR (111-228aa) was over expressed in E. coli and purified by using conventional column chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
13.5 kDa (119aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Si J., et al. (2002) Blood, 100 (13) ; ;4401-9.; ; Zeng M., et al. (2002) J. Biol. Chem. 277 (47) :45611-8.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 0.1M NaCl, 5mM beta-Mercaptoethanol
Scientific Category
Cell Cycle
NCBI Accession Number
NP_002948.1
Uniprot Accession Number
P19793
Species
Human
AA Sequence
MLGLNGVLKV PAHPSGNMAS FTKHICAICG DRSSGKHYGV YSCEGCKGFF KRTVRKDLTY TCRDNKDCLI DKRQRNRCQY CRYQKCLAMG MKREAVQEER QRGKDRNENE VESTSSANE
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