Recombinant human Retinol Binding Protein 4/RBP4 protein
Retinol binding protein 4 (RBP4) belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. This protein was found to be expressed and secreted by adipose tissue, and was strongly associated with insulin resistance. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. Recombinant human RBP4 was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Plasma retinol-binding protein, PRBP, RBP
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
21 kDa (184aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Yao-Borengasser A., et al. (2007) J Clin Endocrinol Metab. 92 (7) :2590-7.; ; McTernan PG., et al. (2007) J Clin Endocrinol Metab. 92 (7) :2430-2.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_006735.2
Uniprot Accession Number
P02753
Species
Human
AA Sequence
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