Recombinant human PTP1B protein

Specific activity is > 10,000 units/mg, and is defined as the amount of enzyme that hydrolyze 1.0 nmole of p-nitrophenyl phosphate (pNPP) per minute at pH 7.5 at 37C.

Protein tyrosine phosphatase non-receptor type 1, PTPN1, PTP1B, PTP-1B, Protein Tyrosine Phosphatase 1B, EC 3.1.3.48, Protein-tyrosine phosphatase1B, Tyrosine-protein phosphatase non-receptor type 1, Protein tyrosine phosphatase non-receptor type 1, Protein Tyrosine Phosphatase Non Receptor Type-1

Specific activity is > 10,000unit/mg, and is defined as the amount of enzyme that hydrolyze 1.0 nmole of p-nitrophenyl phosphate (pNPP) per minute at pH 7.5 at 37C.

PTP1B, Protein tyrosine phosphatase non-receptor type 1, PTPN1, PTP1B, PTP-1B, Protein Tyrosine Phosphatase 1B, EC 3.1.3.48, Protein-tyrosine phosphatase1B, Tyrosine-protein phosphatase non-receptor type 1, Protein tyrosine phosphatase non-receptor type 1, Protein Tyrosine Phosphatase Non Receptor Type-1, PTB2001-10 µg, PTB2001-20 µg, PTB2001-50 µg, PTB2001-100 µg, PTB2001-250 µg, PTB2001-500 µg, PTB2001-1 mg, PTB2001-10, PTB2001-20, PTB2001-50, PTB2001-100, PTB2001-250, PTB2001-500, PTB2001-1

Kimura K et al., Pyrroloquinoline quinone stimulates epithelial cell proliferation by activating epidermal growth factor receptor through redox cycling. (Free Radic Biol Med. 2012) {https://pubmed.ncbi.nlm.nih.gov/22824864/}; ; Maeda A et al., Safranal, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves glucose tolerance in diabetic KK-Ay mice. (Mol Nutr Food Res. 2014) {https://pubmed.ncbi.nlm.nih.gov/24668740/}; ; Quang TH et al., Protein Tyrosine Phosphatase 1B Inhibitors from the Roots of Cudrania tricuspidata. (Molecules. 2015) {https://pubmed.ncbi.nlm.nih.gov/26091075/}; ; Naito Y et al., Bis (hinokitiolato) zinc complex ([Zn (hkt) 2]) activates Akt/protein kinase B independent of insulin signal transduction. (J Biol Inorg Chem. 2016) {https://doi.org/10.1007/s00775-016-1364-9}; ; Cho KH et al., Isolation and structure determination of a new diketopiperazine dimer from marine-derived fungus Aspergillus sp. SF-5280. (Nat Prod Res. 2018) {https://pubmed.ncbi.nlm.nih.gov/28670919/}; ; Park JS et al., Furanoaustinol and 7-acetoxydehydroaustinol: new meroterpenoids from a marine-derived fungal strain Penicillium sp. SF-5497. (J Antibiot (Tokyo) . 2018) {https://pubmed.ncbi.nlm.nih.gov/29463888/}; ; VK Thu et al., Protein tyrosine phosphatase 1B inhibitory triterpene glycosides from Mussaenda pilosissima Valeton. (Phytochemistry Letters. 2020) {https://doi.org/10.1016/j.phytol.2020.01.023.}; ; Kim HJ et al., PTP1B Inhibitory Secondary Metabolites from an Antarctic Fungal Strain Acremonium sp. SF-7394. (Molecules. 2021) {https://pubmed.ncbi.nlm.nih.gov/34576982/}; ; Huong PTM et al., Diterpenoid and phenolic constituents from corn silk (Zea mays) with PTP1B inhibitory activity. (Nat Prod Res. 2023) {https://doi.org/10.1080/14786419.2023.2265038}; ; Tran Thi Hong H et al., Iridoids from the aerial parts of Adenosma caeruleum with their nitric oxide inhibitory effects. (J Mol Struct. 2024) {https://doi.org/10.1016/j.molstruc.2023.137149}; ; Thi Ly Pham et al., PTP1B Inhibitory Activity of Flavonoids from the Roots of Astragalus membranaceus Bunge. (Nat Prod Sci. 2025) {https://doi.org/10.20307/nps.2025.31.1.62}

MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS PFDHSRIKLH QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML NRVMEKGSLK CAQYWPQKEE KEMIFEDTNL KLTLISEDIK SYYTVRQLEL ENLTTQETRE ILHFHYTTWP DFGVPESPAS FLNFLFKVRE SGSLSPEHGP VVVHCSAGIG RSGTFCLADT CLLLMDKRKD PSSVDIKKVL LEMRKFRMGL IQTADQLRFS YLAVIEGAKF IMGDSSVQDQ WKELSHEDLE PPPEHIPPPP RPPKRILEPH N