Recombinant human IPP-POZ (1-157aa) protein
Intracisternal A particle-promoted polypeptide (IPP) is a 66kDa protein (584 amino acids), which contains an N-terminal POZ protein-protein interaction domain and a C-terminla kelch repeat domain consisting of six tandem arranged repeats. The POZ domain (also called BTB domain) is present near the N-terminus of a fraction of zinc finger proteins and in protein that contain the pfam01344 motif such as kelch and pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-coR and SMRT. IPP-POZ domain (1-157aa) was overexpressed in E. coli and purified by using conventional chromatography techniques
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
17.3 kDa (157aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Kim IF., et al. (1999) Gene 228 (1-2), 73-83.; ; Chang-Yeh, A., et al. (1993) Genomics. 15 (1), 239-241.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 10 mM HEPES buffer (pH 7.4) containing 25mM NaCl
Scientific Category
Cell Cycle
NCBI Accession Number
NP_005888
Uniprot Accession Number
Q9Y573
Species
Human
AA Sequence
Frequently Asked Questions
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