Recombinant human IPP-POZ (1-157aa) protein

Intracisternal A particle-promoted polypeptide (IPP) is a 66kDa protein (584 amino acids), which contains an N-terminal POZ protein-protein interaction domain and a C-terminla kelch repeat domain consisting of six tandem arranged repeats. The POZ domain (also called BTB domain) is present near the N-terminus of a fraction of zinc finger proteins and in protein that contain the pfam01344 motif such as kelch and pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-coR and SMRT. IPP-POZ domain (1-157aa) was overexpressed in E. coli and purified by using conventional chromatography techniques

Product Specifications

Product Name Alternative

Intracisternal A particle-promoted polypeptide isoform 1, IPP, KLHL27, IPP-POZ domain, MIPP protein, Kelch-like protein 27, Actin-binding protein IPP, Intracisternal A particle-promoted polypeptide isoform 1, Protein phosphatase inhibitor 1, Actin binding protein IPP, I1, Intracisternal A particle promoted polypeptide, IPP POZ, Kelch like protein 27, Protein phosphatase 1 regulatory subunit 1A

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

17.3 kDa (157aa) confirmed by MALDI-TOF

Additionnal Information

IPP-POZ (1157aa), Intracisternal A particle-promoted polypeptide isoform 1, IPP, KLHL27, IPP-POZ domain, MIPP protein, Kelch-like protein 27, Actin-binding protein IPP, Intracisternal A particle-promoted polypeptide isoform 1, Protein phosphatase inhibitor 1, Actin binding protein IPP, I1, Intracisternal A particle promoted polypeptide, IPP POZ, Kelch like protein 27, Protein phosphatase 1 regulatory subunit 1A, POZ3002-10 µg, POZ3002-20 µg, POZ3002-50 µg, POZ3002-100 µg, POZ3002-250 µg, POZ3002-500 µg, POZ3002-1 mg, POZ3002-10, POZ3002-20, POZ3002-50, POZ3002-100, POZ3002-250, POZ3002-500, POZ3002-1

References & Citations

Kim IF., et al. (1999) Gene 228 (1-2), 73-83.; ; Chang-Yeh, A., et al. (1993) Genomics. 15 (1), 239-241.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 10 mM HEPES buffer (pH 7.4) containing 25mM NaCl

Scientific Category

Cell Cycle

NCBI Accession Number

NP_005888

Uniprot Accession Number

Q9Y573

Species

Human

AA Sequence

MANEDCPKAA DSPFSSDKHA QLILAQINKM RNGQHFCDVQ LQVGQESFKA HRLVLAASSP YFAALFTGGM KESSKDVVPI LGIEAGIFQI LLDFIYTGIV NIGVNNVQEL IIAADMLQLT EVVHLCCEFL KGQIDPLNCI GIFQFSEQIA CHDLLEF