Recombinant human LAIR1 protein
LAIR-1 is a glycoprotein (~32kDa) expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages and dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells and B cells. Lair-1 consists of a leader sequence, extracellular domain, transmembrane domain, cytoplasmic region. The extracellular domain of LAIR-1 (22-125aa) was overexpressed in E. coli, and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
11.7 kDa (105aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Sathish JG., et al. (2001) J Immunol. 166 (3) :1763-70.; ; Meyaard L., et al. (1999) J. Immunol. 162, 5800-4.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 50 mM NaCl, 1mM EDTA
Scientific Category
Immunology
NCBI Accession Number
NP_002278
Uniprot Accession Number
Q6GTX8
Species
Human
AA Sequence
MQEEDLPRPS ISAEPGTVIP LGSHVTFVCR GPVGVQTFRL ERESRSTYND TEDVSQASPS ESEARFRIDS VSEGNAGPYR CIYYKPPKWS EQSDYLELLV KETSG
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