Recombinant human LAIR1 protein

LAIR-1 is a glycoprotein (~32kDa) expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages and dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells and B cells. Lair-1 consists of a leader sequence, extracellular domain, transmembrane domain, cytoplasmic region. The extracellular domain of LAIR-1 (22-125aa) was overexpressed in E. coli, and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Leukocyte-associated immunoglobulin-like receptor 1 isoform a, Lair1, LAIR-1 (Extracellular domain), LAIR-1, mLAIR1, CD305 antigen, Leukocyte-associated immunoglobulin-like receptor 1, Leukocyte-associated immunoglobulin-like receptor 1 isoform a 5133400O11Rik, CD305, D7Bwg0421e, LAIR 1, LAIR1 protein, Leukocyte associated Ig like receptor 1, Leukocyte associated immunoglobulin like receptor 1

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

11.7 kDa (105aa) confirmed by MALDI-TOF

Additionnal Information

LAIR1, Leukocyte-associated immunoglobulin-like receptor 1 isoform a, Lair1, LAIR-1 (Extracellular domain), LAIR-1, mLAIR1, CD305 antigen, Leukocyte-associated immunoglobulin-like receptor 1, Leukocyte-associated immunoglobulin-like receptor 1 isoform a 5133400O11Rik, CD305, D7Bwg0421e, LAIR 1, LAIR1 protein, Leukocyte associated Ig like receptor 1, Leukocyte associated immunoglobulin like receptor 1, LAR3001-10 µg, LAR3001-20 µg, LAR3001-50 µg, LAR3001-100 µg, LAR3001-250 µg, LAR3001-500 µg, LAR3001-1 mg, LAR3001-10, LAR3001-20, LAR3001-50, LAR3001-100, LAR3001-250, LAR3001-500, LAR3001-1

References & Citations

Sathish JG., et al. (2001) J Immunol. 166 (3) :1763-70.; ; Meyaard L., et al. (1999) J. Immunol. 162, 5800-4.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 50 mM NaCl, 1mM EDTA

Scientific Category

Immunology

NCBI Accession Number

NP_002278

Uniprot Accession Number

Q6GTX8

Species

Human

AA Sequence

MQEEDLPRPS ISAEPGTVIP LGSHVTFVCR GPVGVQTFRL ERESRSTYND TEDVSQASPS ESEARFRIDS VSEGNAGPYR CIYYKPPKWS EQSDYLELLV KETSG

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