Recombinant human IRF2 protein
Interferon regulatory factor (IRF) 2 is a member of the interferon regulatory transcription factor family. IRF-2 is generally regarded as an oncoprotein. Structure of IRF1 and IRF2 are similar. However, its functions are different. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. Recombinant human IRF2 was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
15 kDa (133aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Harada, H., et al. (1989) Cell. 58 (4) :729-739 ; ; Matsuyama T., et al. (1993) Cell 75 (1) :83-97 ;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_002190
Uniprot Accession Number
P14316
Species
Human
AA Sequence
MPVERMRMRP WLEEQINSNT IPGLKWLNKE KKIFQIPWMH AARHGWDVEK DAPLFRNWAI HTGKHQPGVD KPDPKTWKAN FRCAMNSLPD IEEVKDKSIK KGNNAFRVYR MLP
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