Recombinant human IL-8/CXCL8 protein

Interleukin-8 (IL-8) is a chemokine, a member of the cytokine family that displays chemotactic activity for specific types of leukocytes. It is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and various tumor cell lines, can produce CXCL8/IL-8 in response to a wide variety of pro-inflammatory stimuli such as exposure to IL-1, TNF, LPS, and viruses. Recombinant human IL-8 was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

C-X-C motif chemokine ligand 8, Interleukin-8, IL-8, C-X-C motif chemokine 8, Emoctakin, Granulocyte chemotactic protein 1, GCP-1, Monocyte-derived neutrophil chemotactic factor, MDNCF, Monocyte-derived neutrophil-activating peptide, MONAP, Neutrophil-activating protein 1, NAP-1, Protein 3-10C, T-cell chemotactic factor, Lung giant cell carcinoma-derived chemotactic protein, Tumor necrosis factor-induced gene 1, Lymphocyte derived neutrophil activating peptide, Beta endothelial cell-derived neutrophil activating peptide, Alveolar macrophage chemotactic factor I, SCYB8, LUCT, LECT, TSG-1, AMCF-I, LYNAP, NAF, b-ENA

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by BCA assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

9 kDa (78aa) confirmed by MALDI-TOF

Additionnal Information

IL8, CXCL8, CXCL8, Neurophil chemotactic factor, NCF, Neutrophil activating protein, NAP, Monocyte derived neutrophil chemotactic factor, MDNCF, T-lymphocyte chemotactic factor, TCF, Granulocyte chemotactic protein, GCP, and Leukocyte adhension inhibitor, LAI, NAP 1, 3 10C, 310C, AMCF 1, AMCF1, b ENAP, Beta thromboglobulin like protein, CXC chemokine ligand 8, CXCL 8, Emoctakin, GCP 1, GCP1, Granulocyte chemotactic protein 1, IL 8, Inteleukin 8, Interleukin8, K 60, LECT, LuCT, Lymphocyte derived neutrophil activating factor, LYNAP, MDNCF, MDNCF a, MDNCF alpha, MONAP, Monocyte derived neutrophil activating protein, Monocyte derived neutrophil chemotactic factor, NAF, NAP1, Neutrophil activating factor, Neutrophil activating protein 1, Protein 3 10C, SCYB 8, SCYB8, T cell chemotactic factor, TSG 1, TSG1, il8, ILH0501-10 µg, ILH0501-20 µg, ILH0501-50 µg, ILH0501-100 µg, ILH0501-250 µg, ILH0501-500 µg, ILH0501-1 mg, ILH0501-10, ILH0501-20, ILH0501-50, ILH0501-100, ILH0501-250, ILH0501-500, ILH0501-1

References & Citations

Mukaida, N., et al. (1992) Microbiol. Immunol. 36, 773-789 ; ; Larsen, C.G., et al. (1989) . Science, 243, 1464-1466; ; Baldwin ET., et al. (1990) . J Biol Chem. 265 (12) :6851-6853 ;

Other References

Kim HR, et al. Anti-cancer activity and mechanistic features of a NK cell activating molecule. (Cancer Immunol Immunother. 2009) {https://pubmed.ncbi.nlm.nih.gov/19259669/}