What is the catalog number for Recombinant human Hexokinase 3 protein?

The catalog number for Recombinant human Hexokinase 3 protein is HXK0701-100.

What sizes are available for Recombinant human Hexokinase 3 protein?

Recombinant human Hexokinase 3 protein is available in the following size(s): 100 µg.

Is Recombinant human Hexokinase 3 protein in stock?

Recombinant human Hexokinase 3 protein is currently made to order / not held in immediate stock. Contact us for lead time.

Recombinant human Hexokinase 3 protein

Hexokinase is the first enzyme in the glycolytic pathway, catalyzing the transfer of a phosphoryl group from ATP to glucose to form glucose-6-phosphate and ADP. In mammals, four distinct enzymes-types 1 to 4 hexokinases-have been identified. The enzyme is found in most cells, but there is tissue specificity for the particular type of hexokinase. Hexokinase3 lacks the hydrophobic N-terminal sequence critical for targeting to mitochondria. Hexpkinase3 may have anabolic functions, providing H6P for glycogen or lipid synthesis. Recombinant human Hexokinase3, fused to His tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

HK3, Hexokinase 3, EC 2.7.1.1, Hexokinase type III, HK III, Hexokinase-3, HKIII, Hexokinase3, HK3, HXK3.

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

101.1 kDa (943aa)

Additionnal Information

Hexokinase3, HK3, Hexokinase 3, EC 2.7.1.1, Hexokinase type III, HK III, Hexokinase-3, HKIII, Hexokinase3, HK3, HXK3., HXK0701-10 µg, HXK0701-20 µg, HXK0701-50 µg, HXK0701-100 µg, HXK0701-250 µg, HXK0701-500 µg, HXK0701-1 mg, HXK0701-10, HXK0701-20, HXK0701-50, HXK0701-100, HXK0701-250, HXK0701-500, HXK0701-1

References & Citations

Jon E. et al., (2003) J.Exp Biology. 206 : 2049-2057; ; Furuta H. et al., (1996) Genomics. 1996; ; 36 (1) :206-9.;

Other References

Tsumura Y, et al. TMG-123, a novel glucokinase activator, exerts durable effects on hyperglycemia without increasing triglyceride in diabetic animal models. (PLoS One. 2017) {https://pubmed.ncbi.nlm.nih.gov/28207836/}

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Signal Transduction

NCBI Accession Number

NP_002106.2

Uniprot Accession Number

P52790

Species

Human

AA Sequence

MDSIGSSGLR QGEETLSCSE EGLPGPSDSS ELVQECLQQF KVTRAQLQQI QASLLGSMEQ ALRGQASPAP AVRMLPTYVG STPHGTEQGD FVVLELGATG ASLRVLWVTL TGIEGHRVEP RSQEFVIPQE VMLGAGQQLF DFAAHCLSEF LDAQPVNKQG LQLGFSFSFP CHQTGLDRST LISWTKGFRC SGVEGQDVVQ LLRDAIRRQG AYNIDVVAVV NDTVGTMMGC EPGVRPCEVG LVVDTGTNAC YMEEARHVAV LDEDRGRVCV SVEWGSFSDD GALGPVLTTF DHTLDHESLN PGAQRFEKMI GGLYLGELVR LVLAHLARCG VLFGGCTSPA LLSQGSILLE HVAEMEDPST GAARVHAILQ DLGLSPGASD VELVQHVCAA VCTRAAQLCA AALAAVLSCL QHSREQQTLQ VAVATGGRVC ERHPRFCSVL QGTVMLLAPE CDVSLIPSVD GGGRGVAMVT AVAARLAAHR RLLEETLAPF RLNHDQLAAV QAQMRKAMAK GLRGEASSLR MLPTFVRATP DGSERGDFLA LDLGGTNFRV LLVRVTTGVQ ITSEIYSIPE TVAQGSGQQL FDHIVDCIVD FQQKQGLSGQ SLPLGFTFSF PCRQLGLDQG ILLNWTKGFK ASDCEGQDVV SLLREAITRR QAVELNVVAI VNDTVGTMMS CGYEDPRCEI GLIVGTGTNA CYMEELRNVA GVPGDSGRMC INMEWGAFGD DGSLAMLSTR FDASVDQASI NPGKQRFEKM ISGMYLGEIV RHILLHLTSL GVLFRGQQIQ RLQTRDIFKT KFLSEIESDS LALRQVRAIL EDLGLPLTSD DALMVLEVCQ AVSQRAAQLC GAGVAAVVEK IRENRGLEEL AVSVGVDGTL YKLHPRFSSL VAATVRELAP RCVVTFLQSE DGSGKGAALV TAVACRLAQL TRV